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Study identifier: NCT03683251 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Extension Study for the Port Delivery System With Ranibizumab (Portal)

Condition: Neovascular Age-Related Macular Degeneration  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants1000
Who can joinAll sexes, 50 Years to no upper limit
Healthy volunteersNo

About this study

This study will evaluate the long-term safety and tolerability of the Port Delivery System with ranibizumab (PDS) (100 mg/mL) in participants with neovascular age-related macular degeneration (nAMD) who have either completed Phase II Study GX28228 (Ladder), Phase III Study GR40548 (Archway), Phase IIIb Study WR42221 (Velodrome), or completed Week 24 visit in Study WR42221 but were not eligible to be randomized in WR42221.

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: GR40549 https://forpatients.roche.com/ No attachments to email below.  ·  888-662-6728 (U.S. and Canada)  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (165)

Retinal Research Institute, LLCPhoenix, Arizona, United StatesCompleted
Arizona Retina and Vitreous ConsultantsPhoenix, Arizona, United StatesCompleted
Barnet Dulaney Perkins Eye CenterPhoenix, Arizona, United StatesActive Not Recruiting
Associated Retina ConsultantsPhoenix, Arizona, United StatesCompleted
Retinal Consultants of ArizonaPhoenix, Arizona, United StatesCompleted
California Retina ConsultantsBakersfield, California, United StatesCompleted
Retina-Vitreous Associates Medical GroupBeverly Hills, California, United StatesCompleted
The Retina PartnersEncino, California, United StatesActive Not Recruiting
Jacobs Retina center at the Shiley eye Institute UCSDLa Jolla, California, United StatesCompleted
Jules Stein Eye Institute/ UCLALos Angeles, California, United StatesCompleted
N CA Retina Vitreous AssocMountain View, California, United StatesCompleted
Retina Consultants, San DiegoPoway, California, United StatesCompleted

+ 153 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT03683251