Condition: Acute Lymphoblastic Leukemia, Adult · Acute Lymphoblastic Leukemia, Pediatric · Chronic Lymphocytic Leukemia · Sponsor: University Hospital Heidelberg
Adult patients with r/r acute lymphoblastic leukemia (ALL) (stratum I), r/r Non-Hodgkin's lymphoma (NHL) including chronic lymphocytic leukaemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) or mantle cell lymphoma (MCL) (stratum II) as well as paediatric patients with r/r ALL (stratum III) will be treated with autologous T-lymphocytes transduced by the third-generation RV-SFG.CD19.CD28.4-1BBzeta retroviral vector. The main purpose of this study is to evaluate safety and feasibility of escalating CD19.CAR T cell doses (0,1-20×20\^7 transduced cells/m\^2) after lymphodepletion with fludarabine and cyclophosphamide.
This description comes directly from the study's public registry record.
Prof. Dr. Michael Schmitt · +49-6221-566614 · michael.schmitt@med.uni-heidelberg.de
Always discuss trial participation with your own doctor first.
| University Hospital Heidelberg | Heidelberg, Germany | Recruiting |
| University Hospital Heidelberg | Heidelberg, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03676504