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Study identifier: NCT03666000 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

Condition: Non-Hodgkin Lymphoma · B-cell Acute Lymphoblastic Leukemia · Chronic Lymphocytic Leukemia  ·  Sponsor: Imugene Limited

PhasePhase 1
Planned participants135
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 1/1b, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of azer-cel, an allogeneic anti-CD19 CAR T, in adults with r/r B ALL, r/r B-cell NHL and CLL/SLL.

This description comes directly from the study's public registry record.

Talk to the study team

Imugene Clinical Team  ·  +1 984 245 0082  ·  info@imugene.com

Imugene Clinical Team  ·  +61 2 9423 0881  ·  info@imugene.com

Always discuss trial participation with your own doctor first.

Locations (23)

Banner MD Anderson Cancer CenterGilbert, Arizona, United StatesCompleted
City of HopeDuarte, California, United StatesCompleted
H. Lee Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Winship Cancer Institute Emory UniversityAtlanta, Georgia, United StatesRecruiting
Northside Hospital Cancer InstituteAtlanta, Georgia, United StatesRecruiting
University of MarylandBaltimore, Maryland, United StatesRecruiting
Tufts Medical CenterBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesCompleted
Barbara Ann Karmanos Cancer Institute (Wayne State University)Detroit, Michigan, United StatesCompleted
University of MinnesotaMinneapolis, Minnesota, United StatesRecruiting
Weill Cornell Medical College - NY Presbyterian HospitalNew York, New York, United StatesCompleted
Columbia University Irving Medical Center/New York Presbyterian HospitalNew York, New York, United StatesRecruiting

+ 11 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT03666000