Condition: Stevens-Johnson Syndrome · Lyell Syndrome · Drug Reactions · Sponsor: Assistance Publique - Hôpitaux de Paris
Intro: Dermatology department of Henri Mondor Hospital (Creteil, France), is a reference center for toxic bullous diseases and severe cutaneous drug reactions (Stevens-Johnson syndrome (SJS), Lyell syndrome (toxic epidermal necrolysis (TEN)), generalized bullous fixed drug reactions, AGEP, DRESS, drug induced immunoglobulin A (IgA) bullous dermatosis, and erythema multiforme). In order to conduct clinical and biological research studies in drug reactions, it is necessary for the investigator's department to implement a collection of clinical data and biological samples. Hypothesis/Objective: To collect clinical data and cutaneous and biological samples for immunological, biological and genetic studies to improve knowledge about pathophysiology of drug reactions. Method: The following samples will be performed in addition to the routine practice samples: one skin punch biopsy (6mm); 43 mL of blood; blister fluid aspiration; oral and nose mucous membrane and skin eSWABs, stool samples. These samples will be stored in a dedicated biological sampling department ("Platform of biological resources"). Conclusion: The implementation of this collection should allow us to conduct pathophysiological studies about drug reactions.
This description comes directly from the study's public registry record.
Saskia Oro, MD · 0149812536 · saskia.oro@aphp.fr
Laetitia Gregoire · 0149814164 · laetitia.gregoire@aphp.fr
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| Henri Mondor | Créteil, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03659227