Condition: Sleep Initiation and Maintenance Disorders · Stress Disorders, Posttraumatic · Sponsor: VA Office of Research and Development
Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances. Poor sleep, one of the most common complaints in Veterans with PTSD, can be distressing, impair concentration and memory, and contribute to physical health conditions, such as metabolic syndrome, inflammation, and cardiovascular disease. The orexin neuropeptide system underlies both sleep and stress reactivity. Suvorexant, a drug that reduces orexin, improves sleep in civilians, but has not yet been tested in Veterans with PTSD. This study will test whether suvorexant can improve sleep disturbances and PTSD symptoms in Veterans. Suvorexant may benefit Veterans by improving sleep quickly while also reducing PTSD symptoms over the long term, and with fewer side effects that were common in previous medications used to treat these conditions. Improving Veterans' sleep and PTSD symptoms could lead to better emotional and physical well-being, quality of life, relationships, and functioning.
This description comes directly from the study's public registry record.
Sabra S Inslicht, PhD · (415) 221-4810 · sabra.inslicht@va.gov
Always discuss trial participation with your own doctor first.
| VA Long Beach Healthcare System, Long Beach, CA | Long Beach, California, United States | Recruiting |
| San Francisco VA Medical Center, San Francisco, CA | San Francisco, California, United States | Recruiting |
| Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC | Salisbury, North Carolina, United States | Recruiting |
| Ralph H. Johnson VA Medical Center, Charleston, SC | Charleston, South Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03642028