Condition: Anatomic Stage IV Breast Cancer AJCC v8 · Invasive Breast Carcinoma · Metastatic Triple-Negative Breast Carcinoma · Sponsor: National Cancer Institute (NCI)
This phase II trial studies how well nab-paclitaxel, durvalumab, and tremelimumab with or without personalized synthetic long peptide vaccine (neoantigen vaccine) works in treating patients with triple negative breast cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Chemotherapy drugs, such as nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as durvalumab and tremelimumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Vaccines made from peptides may help the body build an effective immune response to kill tumor cells. It is not yet known whether giving nab-paclitaxel, durvalumab, and tremelimumab with or without neoantigen vaccine will work better in treating patients with triple negative breast cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange, California, United States | Active Not Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Terminated |
| UCHealth University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford, Connecticut, United States | Active Not Recruiting |
| Yale University | New Haven, Connecticut, United States | Active Not Recruiting |
| UM Sylvester Comprehensive Cancer Center at Aventura | Aventura, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | Recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation, Florida, United States | Recruiting |
| Moffitt Cancer Center-International Plaza | Tampa, Florida, United States | Recruiting |
+ 18 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03606967