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Study identifier: NCT03595917 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML

Condition: B-cell Acute Lymphoblastic Leukemia · Chronic Myeloid Leukemia (CML) in Lymphoid Blast Crisis · Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Ph+ ALL  ·  Sponsor: Marlise Luskin, MD

PhasePhase 1
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research study is evaluating a drug called ABL001 taken in combination with dasatinib (Sprycel®) and prednisone (a steroid) as a possible treatment for B-cell Acute Lymphoblastic Leukemia that is BCR-ABL positive (BCR-ABL+ B-ALL) or Chronic Myeloid Leukemia (CML) in lymphoid blast crisis. BCR-ABL+ B-ALL is also called Philadelphia chromosome positive Acute Lymphoblastic Leukemia (Ph+ ALL). It is expected that 40-65 people will take part in this research study. * ABL001 * Dasatinib (Sprycel®) * Prednisone * Blinatumomab

This description comes directly from the study's public registry record.

Talk to the study team

Marlise R. Luskin, MD  ·  617-632-1906  ·  Marlise_Luskin@DFCI.HARVARD.edu

Always discuss trial participation with your own doctor first.

Locations (4)

University of Chicago Comprehensive Cancer CenterChicago, Illinois, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Roswell Park Comprehensive Cancer CenterBuffalo, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03595917