Condition: Systemic Sclerosis · Dermatomyositis · iPPSD2 · Sponsor: University Hospital, Limoges
Ectopic soft tissue calcifications or ossifications can complicate the course of numerous diseases; most of them are rare or very rare. Even if the clinical, radiological and pathological presentation of ectopic calcifications and ossifications are different, the same hypotheses are discussed considering their hypothetical pathophysiology. Indeed, high calcium phosphate product, local cellular lesions and abnormal transdifferentiation of mesenchymal cells are regularly evoked when pathophysiology of such calcifications or ossifications are discussed. Apart from several case reports that have not been confirmed so far, no medical treatments are available, leading to significant pain and impairment of quality of life for patients. Therefore, only surgical treatment can be proposed when the volume or the consequences of these calcifications/ossifications become too important. Sodium thiosulfate (STS) is currently used as a cyanide poisoning antagonist and a chemoprotectant against adverse effects of several chemotherapies such as Cisplatin. Numerous case reports and several studies have revealed the potential interest of STS in the treatment of uremic induced vascular or soft tissues calcifications. Recently, our group has developed an expertise in the use of STS for the treatment of ectopic soft tissue calcifications or ossifications. Considering these promising preliminary data, and their limits, we developed a strategy to treat soft tissue calcifications or ossifications bas…
This description comes directly from the study's public registry record.
Vincent GUIGONIS, MD · 555056358 · vincent.guigonis@unilim.fr
Claire BAHANS · claire.bahans@chu-limoges.fr
Always discuss trial participation with your own doctor first.
| CHU de BORDEAUX | Bordeaux, France | Recruiting |
| Hospice Civil de Lyon | Bron, France | Not Yet Recruiting |
| ApHp - Hôpital Bicêtre | Le Kremlin-Bicêtre, France | Recruiting |
| CHU de Limoges | Limoges, France | Recruiting |
| ApHp - hôpital Lariboisière | Paris, France | Recruiting |
| Hôpital de la Pitié Salpétriêre | Paris, France | Not Yet Recruiting |
| CHU de ROUEN | Rouen, France | Not Yet Recruiting |
| CHU de Toulouse | Toulouse, France | Recruiting |
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT03582800