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Study identifier: NCT03579875 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

Condition: Fanconi Anemia · Severe Aplastic Anemia · Myelodysplastic Syndromes  ·  Sponsor: Masonic Cancer Center, University of Minnesota

PhasePhase 2
Planned participants48
Who can joinAll sexes, N/A to 65 Years
Healthy volunteersNo

About this study

This is a phase II trial of T cell receptor alpha/beta depletion (α/β TCD) peripheral blood stem cell (PBSC) transplantation in patients with inherited bone marrow failure (BMF) disorders to eliminate the need for routine graft-versus-host disease (GVHD) immune suppression leading to earlier immune recovery and potentially a reduction in the risk of severe infections after transplantation.

This description comes directly from the study's public registry record.

Talk to the study team

Margaret MacMillan, MD, Msc, FRCPC  ·  612-626-2961  ·  macmi002@umn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Masonic Cancer Center at University of MinnesotaMinneapolis, Minnesota, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03579875