Condition: Primary Bilary Cirrhosis (PBC) · Autoimmune Hepatitis · Overlap Syndrome · Sponsor: University Health Network, Toronto
CaNAL is a longitudinal observational cohort study of patients diagnosed with Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), or overlap syndrome. This study creates a nationwide registry and network focusing on high quality long-term follow-up of individual patient data from major Canadian centers. Primary Biliary Cholangitis (PBC) and Autoimmune Hepatitis (AIH) are rare and slowly progressive liver diseases associated with development of cirrhosis, liver cancer (HCC) and liver failure requiring liver transplantation or leading to premature death. The rarity and slowly progressive nature of these autoimmune liver diseases make them difficult to study and only a large scale approach combining patient data from multiple centers across Canada will allow new insights. The primary aim of the Canadian Network for Autoimmune Liver Disease is to build a Canadian registry of patients with PBC, AIH, and overlap syndrome. We capture patient characteristics, laboratory assessments and natural history, patient-reported outcomes including quality of life measures and environmental exposures, response to treatment, and pre- and post-transplant outcomes. We will then identify risk factors associated with critical outcomes for the patient, including response to treatment, progression to transplant, risk of liver cancer, and recurrent disease after transplant. We can identify biomarkers (biochemical indicators of progression of disease) to help diagnose autoimmune liver diseas…
This description comes directly from the study's public registry record.
Surain Roberts, AB · 613 291 5039 · surain.roberts@uhn.ca
Kattleya Tirona, BA, CCRP · 416 340 4800 · kattleya.tirona@uhn.ca
Always discuss trial participation with your own doctor first.
| Foothills Medical Centre | Calgary, Alberta, Canada | Not Yet Recruiting |
| University of Alberta Hospital | Edmonton, Alberta, Canada | Recruiting |
| Vancouver General Hospital | Vancouver, British Columbia, Canada | Not Yet Recruiting |
| St. Paul's Hospital | Vancouver, British Columbia, Canada | Not Yet Recruiting |
| Health Sciences Centre | Winnipeg, Manitoba, Canada | Not Yet Recruiting |
| Queen Elizabeth II Health Sciences Centre | Halifax, Nova Scotia, Canada | Active Not Recruiting |
| McMaster University Medical Centre | Hamilton, Ontario, Canada | Not Yet Recruiting |
| Kingston Health Sciences Centre (HDH Site) | Kingston, Ontario, Canada | Active Not Recruiting |
| London Health Sciences Centre - University Hospital | London, Ontario, Canada | Recruiting |
| The Ottawa Hospital | Ottawa, Ontario, Canada | Recruiting |
| Toronto General Hospital | Toronto, Ontario, Canada | Recruiting |
| Centre hospitalier de l'Université de Montréal | Montreal, Quebec, Canada | Recruiting |
+ 3 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03569826