Condition: Acute Pancreatitis · Complication · Mortality Rate · Sponsor: Peking Union Medical College Hospital
Acute pancreatitis (AP) is an inflammatory condition of the pancreas following the activated pancreatic enzymes induced by varied causes, with or without other organ(s) dysfunction. The production and release of inflammatory factors is generally considered as the key factor of pathogenesis. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly applied agents for inflammatory diseases. A series studies have proved that indomethacin can reduce the risk of post-endoscopic retrograde cholangiopancreatography (ERCP), but high-quality evidence is still lacking in the field of effectiveness of NSAIDs to treat, rather than prevent, other types of AP. Majority of animal experiments showed that NSAIDs had protective effects for organ functions, but the results of several preliminary clinical studies were inconsistent. Randomized controlled trials are eagerly awaited to elucidate its effects on AP.
This description comes directly from the study's public registry record.
Dong Wu, M.D. · 8618612671010 · dongwu@pumc.edu.cn
Always discuss trial participation with your own doctor first.
| Peking University Sixth Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Peking Union Medical College Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Liangxiang Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Guiyang Second People's Hospital | Guiyang, Guizhou, China | Recruiting |
| Baoding Seventh Hospital | Baoding, Hebei, China | Recruiting |
| Fourth Affiliated Hospital of Harbin Medical University | Harbin, Heilongjiang, China | Recruiting |
| Dengzhou People's Hospital | Dengzhou, Henan, China | Recruiting |
| Second People Hospital of Nanyang | Nanyang, Henan, China | Recruiting |
| The Second People's Hospital of Huai'an | Huaian, Jiangsu, China | Recruiting |
| Nantong First People's Hospital | Nantong, Jiangsu, China | Recruiting |
| Suqian People's Hospital | Suqian, Jiangsu, China | Recruiting |
| Wuxi Third People's Hospital | Wuxi, Jiangsu, China | Recruiting |
+ 5 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03547232