Condition: Ascending Aortic Aneurysm Enlargement · Ascending Aorta Aneurysm · Sponsor: Ottawa Heart Institute Research Corporation
The ascending aorta conducts blood from the heart to the rest of the body. The ascending aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger aorta. When the ascending aorta tears or ruptures, the risk dying is high even if surgery is done as soon as possible. Traditionally, when the ascending aorta gets above 5.5 cm, surgery is recommended to replace the aorta. However, this threshold is based relatively weak evidence, and sometimes patients with smaller aorta can tear or rupture. On the other hand, surgery carries its own risk as well. Since there are risk of waiting or doing surgery, there is currently no great support for either approach for patients with a smaller aorta. In the TITAN SvS trial, patients with an ascending aorta between 5.0 to 5.5 cm is assigned by chance to the early surgery group, in which they will undergo replacement of aorta, or the surveillance group, in which they will be closely monitored. The chance of dying or suffer tearing or rupture of aorta between the two groups will be compared. The result of the trial will guide future practice for patients with enlarged ascending aorta. This is a prospective, multi-centre randomized control trial that compares the all-cause mortality, aneurysm-related aortic events, rate of stroke, and quality of life for those patients undergoing early elective ascending aortic surgery to those patients undergoing surveillance. Patients referred for an ascending aortic aneurysm tha…
This description comes directly from the study's public registry record.
Khatira Mehdiyeva · 613-696-7000 · kmehdiyeva@ottawaheart.ca
Alice Black · 613-696-7230 · alblack@ottawaheart.ca
Always discuss trial participation with your own doctor first.
| University of California at San Francisco Medical Center | San Francisco, California, United States | Recruiting |
| Massachusetts General Hospital | Boston, Massachusetts, United States | Recruiting |
| Beth Israel Deaconess Medical Center | Boston, Massachusetts, United States | Recruiting |
| University of Michigan | Ann Arbor, Michigan, United States | Recruiting |
| Mayo Clinic | Rochester, Minnesota, United States | Recruiting |
| Washington University School of Medicine | St Louis, Missouri, United States | Recruiting |
| The Valley Hospital, Inc | Ridgewood, New Jersey, United States | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York, New York, United States | Recruiting |
| Duke University | Durham, North Carolina, United States | Recruiting |
| University Hospitals Cleveland | Cleveland, Ohio, United States | Recruiting |
| Ohio State University Medical Center | Columbus, Ohio, United States | Recruiting |
| The Trustees of the University of Pennsylvania | Philadelphia, Pennsylvania, United States | Recruiting |
+ 16 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03536312