Condition: B-cell Acute Lymphoblastic Leukemia · Sponsor: Pediatric Transplantation & Cellular Therapy Consortium
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regimen as part of the treatment cohort of the study. Subjects who are pre-HCT NGS-MRD positive will be treated as per treating center standard and will be followed in an observational cohort (HCT center standard of care).
This description comes directly from the study's public registry record.
Liz Gourdine · 323-361-6652 · EndRAD@chla.usc.edu
Always discuss trial participation with your own doctor first.
| Children's of Alabama/University of Alabama in Birmingham(UAB) | Birmingham, Alabama, United States | Recruiting |
| Phoenix Children's Hospital | Phoenix, Arizona, United States | Recruiting |
| City of Hope | Duarte, California, United States | Recruiting |
| Children's Hospital Los Angeles | Los Angeles, California, United States | Recruiting |
| UCLA Mattel Children's Hospital | Los Angeles, California, United States | Recruiting |
| UCSF Benioff Children's Hospital Oakland | Oakland, California, United States | Recruiting |
| UCSF | San Francisco, California, United States | Recruiting |
| Children's Hospital Colorado | Aurora, Colorado, United States | Recruiting |
| Yale University School of Medicine | New Haven, Connecticut, United States | Recruiting |
| Alfred I. duPont Hospital for Children - Nemours Deleware | Wilmington, Delaware, United States | Recruiting |
| University of Florida | Gainesville, Florida, United States | Recruiting |
| Nicklaus Children's Hospital | Miami, Florida, United States | Recruiting |
+ 12 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03509961