Condition: Infertility · Sponsor: University of Luebeck
Rationale: The hormone progesterone has different functions. In pregnancy, it is vital for maintenance thereof. In early pregnancy, progesterone is synthesized by the Corpus luteum (CL). Its production shifts from the CL to the placenta after several gestational weeks. This process is termed luteoplacental shift. Still, the exact time point of the luteoplacental shift remains unknown. Furthermore, the characteristics of placental progesterone increase and its relevance for the course of pregnancy has not been studied so far. Furthermore, recent studies have shown an influence of abnormal vaginal microbiota on the likelihood to achieve and maintain pregnancy. Little is known about possible crosslinks between endocrinology and vaginal/endometrial microbiota which is why this study aims to investigate possible associations of such kind. Objective: The primary objective of this study is to evaluate the time point of the luteoplacental shift in patients achieving pregnancy after transfer of cryopreserved embryos subsequently to IVF/ICSI cycles. Secondary objectives are to study the characteristics of the placental progesterone increase and its function as a predictor of the course and development of pregnancies and to study vaginal/endometrial microbiota at baseline and changes associated with shift into luteal phase and early pregnancy and how this potentially relates to pregnancy outcome. Study Design: Prospective, multi-center, observational clinical cohort study. For the…
This description comes directly from the study's public registry record.
Georg Griesinger, MD · +49451 50577810 · georg.griesinger@uni-luebeck.de
Tanja Eggersmann, MD · +49451 50577810 · tanja.eggersmann@uksh.de
Always discuss trial participation with your own doctor first.
| IVF-SAAR | Saarbrücken, Saarland, Germany | Recruiting |
| Universitäres Kinderwunschzentrum Lübeck | Lübeck, Schleswig-Holstein, Germany | Recruiting |
| Universitätsklinikum Düsseldorf,UniKiD | Düsseldorf, Germany | Recruiting |
| Universitäres Kinderwunschzentrum | Kiel, Germany | Recruiting |
| University of Luebeck | Lübeck, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03507673