Condition: Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7 · Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7 · Sponsor: ECOG-ACRIN Cancer Research Group
This randomized phase II trial studies how well chemotherapy before surgery and radiation therapy works compared to surgery and radiation therapy alone in treating patients with nasal and paranasal sinus cancer that can be removed by surgery. Drugs used in chemotherapy, such as docetaxel, cisplatin, and carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy before surgery and radiation therapy may make the tumor smaller and reduce the amount of normal tissue that needs to be removed and treated with radiation.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| University of Arizona Cancer Center-Orange Grove Campus | Tucson, Arizona, United States | Recruiting |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | Recruiting |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | Recruiting |
| Mercy Hospital Fort Smith | Fort Smith, Arkansas, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Withdrawn |
| Stanford Cancer Institute Palo Alto | Palo Alto, California, United States | Recruiting |
| VA Palo Alto Health Care System | Palo Alto, California, United States | Recruiting |
| Smilow Cancer Center/Yale-New Haven Hospital | New Haven, Connecticut, United States | Recruiting |
| Yale University | New Haven, Connecticut, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | Suspended |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | Recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida, United States | Recruiting |
+ 128 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03493425