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Study identifier: NCT03492151 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions

Condition: Pancreatic Cyst  ·  Sponsor: Ohio State University Comprehensive Cancer Center

PhaseN/A
Planned participants500
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The study schema is shown in Figure 4. (A) All patients referred to one of the participating academic centers for EUS evaluation of the PCL will be enrolled in the protocol if they satisfy inclusion criteria. Patient consent will be obtained during the clinic visit or prior to their EUS. EUS-guided nCLE imaging is first performed (B) followed by EUS-guided FNA and aspiration of cyst fluid. The cyst fluid is analyzed for CEA and cytology. As per institutional standard of care, the cyst fluid is also sent for molecular analysis. The results of the cyst fluid molecular analysis (B) will be utilized for the most likely diagnosis. Based on institutional multidisciplinary tumor board meetings, surgery is performed as indicated (C). Surgical histopathology serves as "gold standard" for diagnosis. It is anticipated that the majority of patients will undergo surgical resection after their EUS.

This description comes directly from the study's public registry record.

Talk to the study team

Megan Fry  ·  614-293-1056  ·  Megan.Fry@osumc.edu

Diana Burke  ·  Diana.Burke@osumc.edu

Always discuss trial participation with your own doctor first.

Locations (10)

Mayo Clinic Scottsdale CampusScottsdale, Arizona, United StatesRecruiting
Stanford HospitalStanford, California, United StatesRecruiting
Yale School of MedicineNew Haven, Connecticut, United StatesRecruiting
Parkview Hospital RandalliaFort Wayne, Indiana, United StatesActive Not Recruiting
The Johns Hopkins HospitalBaltimore, Maryland, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
NYU Langone HealthGarden City, New York, United StatesRecruiting
Icahn School of Medicine at Mount SinaiNew York, New York, United StatesRecruiting
The Ohio State University Wexner Medical CenterColumbus, Ohio, United StatesRecruiting
Baylor College of MedicineHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03492151