Condition: Colorectal Cancer Metastatic · Liver Metastases · Sponsor: Jena University Hospital
Nearly one third of patients with colorectal cancer develop liver metastases. It is well known that the achievement of a R0-situation is one of the most important factors for a positive long-term outcome. Despite further advantages in multimodal treatment concepts, only 20 - 30 % of the patients with metastases can be resected in curative intention. Recent studies, especially from Norway, have shown that liver transplantation might be a feasible option in well selected patients since the complete hepatectomy with subsequent liver transplantation can be an option for the achievement of a R0 situation. In this study, we pursue the strategy of two-stage hepatectomy combined with a left-lateral living donor liver transplantation. Inclusion criteria are as follows: non-resectable liver metastases of a primary colorectal carcinoma with an assumed portal-venous drainage of the tumor and at least a "stable disease" after a period of eight weeks systemic chemotherapy. Patients are excluded from the study if there is an extrahepatic tumor burden (with the exception of resectable lung metastases) or if the patient is not suitable for liver transplantation due to co-morbidities. The transplantation itself will be undertaken as a living donor liver transplantation where the left lateral liver lobe (liver segments 2 \& 3) from a healthy volunteer donor will serve as graft. Prior transplantation, a left hemihepatectomy in the recipient is performed and the left lateral graft will be tra…
This description comes directly from the study's public registry record.
Falk Rauchfuss, M.D., M.Sc. · 004936419322601 · Falk.Rauchfuss@med.uni-jena.de
Ulrike McCaulley, Study Nurse · 004936419322694 · Ulrike.McCaulley@med.uni-jena.de
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| Jena University Hospital | Jena, Germany | Recruiting |
| University Hospital Tübingen | Tübingen, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03488953