Condition: Small Cell Lung Cancer · Sponsor: Centre Antoine Lacassagne
The investigators propose to study the carbonic anhydrase inhibition (acetazolamide) associated with concomitant radiochemotherapy or radioimmunotherapy in small cell lung cancer due to: 1. The over-expression of carbonic anhydrases in this type of cancer, 2. The Anti-tumor effect in preclinical acetazolamide in various tumor lines including neuroendocrine tumor lines, 3. The observed synergy between irradiation and inhibition of carbonic anhydrases, 4. Potential anti-tumor immune effect caused by decreased extracellular acidity.
This description comes directly from the study's public registry record.
Jérôme DOYEN, PH · +33492031270 · jerome.doyen@nice.unicancer.fr
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| Centre Antoine Lacassagne | Nice, France | Recruiting |
| Centre Hospitalier Princesse grace | Monte Carlo, Monaco | Terminated |
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Source record: clinicaltrials.gov/study/NCT03467360