Condition: HIV · Seroconversion, HIV · Sponsor: University Hospital, Ghent
In this prospective longitudinal study we aim to assess how immunologic and viral aspects of the human immunodeficiency virus (HIV) viral reservoir, established during early HIV infection and responsible for viral rebound at treatment interruption, evolve in individuals who start combination anti-retroviral therapy (cART) during acute seroconversion. Recently infected patients will be selected based on Fiebig staging for an in depth sampling protocol at different timepoints during a 2 year follow up period. Colonbiopsies, lymphnode resection, lumbar puncture, leucapheresis and repeated peripheral venous blood-draws will be performed. Immunological, virological and genome expression analysis will be performed on the gathered samples.
This description comes directly from the study's public registry record.
Linos Vandekerckhove, Prof. Dr. · +3293323398 · linos.vandekerckhove@ugent.be
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| UZ Gent | Ghent, Oost-Vlaanderen, Belgium | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03449706