Condition: Chronic Rhinosinusitis (Diagnosis) · Sponsor: University of Alabama at Birmingham
The purpose of this pilot study is to explore wither ivacaftor in refractory CRS patients will demonstrate safety and tolerability; restore CFTR-mediated Cl- secretions as measured by EDSPD testing; produce detectable improvements in validated measures of CRS including the SNOT-22 questionnaire, Lund-MacKay CT scan grading, and Lund-Kennedy endoscopic scores; and provide beneficial effects on readily measured markers of sinonasal inflammation and infection (IP-10, IL-8, and Pseudomonas CFUs).
This description comes directly from the study's public registry record.
Norma Miller, RN · (205) 975-6169 · ncmiller@uabmc.edu
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| University of Alabama at Birmingham | Birmingham, Alabama, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03439865