Condition: Cardiotoxicity · HER2/Neu Positive · Metastatic Malignant Neoplasm in the Brain · Sponsor: SWOG Cancer Research Network
This trial has two cohorts of patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. All patients must be receiving trastuzumab-based treatment. Both cohorts are being observed for cardiac toxicity. The largest cohort (currently open to accrual) is observational, and contains patients who are taking a beta blocker, ACE inhibitor, or ARB as well as their trastuzumab-based treatment. The goal is to understand how common cardiac problems are in this group of patients at high risk. The smaller cohort (currently closed to accrual) is randomized. Patients in this second cohort are randomized to either carvedilol or no treatment, with the goal of seeing whether carvedilol (used to treat heart failure and high blood pressure) may prevent the heart from side effects of chemotherapy.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Anchorage Associates in Radiation Medicine | Anchorage, Alaska, United States | Suspended |
| Alaska Breast Care and Surgery LLC | Anchorage, Alaska, United States | Suspended |
| Alaska Oncology and Hematology LLC | Anchorage, Alaska, United States | Suspended |
| Alaska Women's Cancer Care | Anchorage, Alaska, United States | Suspended |
| Anchorage Oncology Centre | Anchorage, Alaska, United States | Suspended |
| Katmai Oncology Group | Anchorage, Alaska, United States | Suspended |
| Providence Alaska Medical Center | Anchorage, Alaska, United States | Suspended |
| Fairbanks Memorial Hospital | Fairbanks, Alaska, United States | Suspended |
| CHI Saint Vincent Cancer Center Hot Springs | Hot Springs, Arkansas, United States | Suspended |
| Kaiser Permanente-Deer Valley Medical Center | Antioch, California, United States | Active Not Recruiting |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank, California, United States | Suspended |
| Enloe Medical Center | Chico, California, United States | Active Not Recruiting |
+ 578 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03418961