Condition: Carcinoma, Squamous Cell · Sponsor: Melissa Pugliano-Mauro
This clinical trial proposes to evaluate a relatively unexplored approach to treatment of squamous cell carcinoma (SCC) on the lower extremities. The strategy is to directly and specifically deliver drug to the tumor. For the proposed phase I clinical trial, the investigators will perform intralesional injections of a well characterized, potent chemotherapeutic agent 5-fluorouracil (5FU) with and without a topical application of 0.005% calcipotriene cream to kill topically accessible SCC cells. The goal of the study is to evaluate the safety profile and tolerability of intralesional-5FU with and without a concomitant topical calcipotriene and measure the clinical objective response rate (ORR) in treated lesions compared to untreated lesions 3 weeks after treatment.
This description comes directly from the study's public registry record.
Melissa Pugliano-Mauro, MD · (412) 996-6428 · puglianomauroma@upmc.edu
Jeff Plowey, MS · (412) 724-7375 · ploweyjm2@upmc.edu
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| St. Margaret Hospital Dermatology | Pittsburgh, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03370406