Condition: Type1 Diabetes Mellitus · Sponsor: University of Exeter
Type 1 diabetes (T1D) results from destruction of insulin-producing beta cells in the pancreas by the body's own immune system (autoimmunity). It is not fully understood what causes this type of diabetes and why there is variation in age of onset and severity between people who develop the disease. The aim of this work is to study very unusual people who develop T1D extremely young, as babies under 2 years of age (EET1D). The investigators think that, for the condition to have developed that early, they must have an unusual or extreme form of autoimmunity. Studying people with EET1D will enable us to look at exactly what goes wrong with the immune system because they have one of the most extreme forms of the disease. Much may be learned about the disease from a small number of rare individuals. The investigators aim to confirm that they have autoimmune type 1 diabetes and then try to understand how they have developed diabetes so young by studying their immune system genes, the function of their immune system, and environmental factors (such as maternal genetics) that may play a role in their development of the disease. People with diabetes diagnosed under 12 months are very rare, live all over the world. and are usually referred to Exeter for genetic testing. Individuals will be contacted via their clinician to ask for more information about their diabetes and their family history. Samples will be collected to study whether they still make any of their own insulin and whet…
This description comes directly from the study's public registry record.
Richard Oram · +44 (0) 1392 408538 · r.oram@exeter.ac.uk
Michelle Hudson · +44 (0) 1392 408181 · m.hudson@exeter.ac.uk
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| Benaroya Research Institute | Seattle, Washington, United States | Not Yet Recruiting |
| Leiden University Medical Center | Leiden, Leiden, Netherlands | Not Yet Recruiting |
| Royal Devon & Exeter NHS Foundation Trust | Exeter, Devon, United Kingdom | Recruiting |
| King's College London | London, United Kingdom | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT03369821