Condition: Depression · Sponsor: Chinese University of Hong Kong
Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst treatment-resistant depression has remained substantial despite the health care cost and time incurred. There remains a compelling clinical need to find valid biomarkers to inform personalized treatment. Using supervised machine learning on 4 combined features of neuroimaging markers, our group recently reported excellent prediction for clinical response in 70 patients receiving TMS to left dorsolateral prefrontal cortex for medication-resistant major depression in 2015-18 (Phase 1 study).The clinical utility of these potential neuroimaging biomarkers is still uncertain without further validation of the trained model in an independent clinical cohort.
This description comes directly from the study's public registry record.
The Department of Psychiatry · 852-2607-6027 · psychiatry@cuhk.edu.hk
Helene J Hopman · 852-5597-1622 · hjhopman@link.cuhk.edu.hk
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| Department of Psychiatry, CUHK | Hong Kong, Hong Kong | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03348761