Condition: Juvenile Myelomonocytic Leukemia · Recurrent Acute Biphenotypic Leukemia · Recurrent Acute Undifferentiated Leukemia · Sponsor: Fred Hutchinson Cancer Center
This phase I trial studies the side effects and best dose of CD4+ and CD8+ HA-1 T cell receptor (TCR) (HA-1 T TCR) T cells in treating patients with acute leukemia that persists, has come back (recurrent) or does not respond to treatment (refractory) following donor stem cell transplant. T cell receptor is a special protein on T cells that helps them recognize proteins on other cells including leukemia. HA-1 is a protein that is present on the surface of some peoples' blood cells, including leukemia. HA-1 T cell immunotherapy enables genes to be added to the donor cells to make them recognize HA-1 markers on leukemia cells.
This description comes directly from the study's public registry record.
FHCC Immunotherapy Intake · 206-606-4668 · immunotherapy@fredhutch.org
FHCC Immunotherapy Intake · 855-557-0555
Always discuss trial participation with your own doctor first.
| Fred Hutch/University of Washington Cancer Consortium | Seattle, Washington, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03326921