Condition: Acute Myeloid Leukemia · Myelodysplastic Syndromes · Sponsor: University Hospital, Basel, Switzerland
The study examines the application of expanded natural killer cells (NK cells) following haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) for AML or MDS. Haplo-HSCT is a preferred treatment option for patients with AML or MDS without a HLA-matched donor. With administration of cyclophosphamide post-transplant , the safety of the procedure is similar to a HSCT from a HLA-identical donor. Relapse of AML/MDS represents a serious problem following haplo-HSCT. NK cells are immune cells able to destroy tumor cells. Their potency has been established particularly in the setting of a haplo-HSCT. In the current study, study participants undergoing haplo-HSCT will receive expanded NK cells from their respective stem-cell donors following haplo-HSCT. The primary goal of the study is to establish the safety and feasibility of this approach. In addition, the activity of the NK cells will be examined.
This description comes directly from the study's public registry record.
Matyas Ecsedi, MD-PhD · +41612652525 · matyas.ecsedi@usb.ch
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| University Hospital Basel | Basel, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03300492