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Study identifier: NCT03295981 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

Condition: Giant Cell Tumor of Bone  ·  Sponsor: St. Louis University

PhasePhase 3
Planned participants120
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.

This description comes directly from the study's public registry record.

Talk to the study team

Allison Gruender, RN  ·  314-617-3406  ·  allison.gruender@health.slu.edu

Marsha Steffen, RN  ·  314-617-3410  ·  marsha.steffen@slucare.ssmhealth.com

Always discuss trial participation with your own doctor first.

Locations (16)

University of California - Los AngelesLos Angeles, California, United StatesRecruiting
Indiana UniversityIndianapolis, Indiana, United StatesRecruiting
University of IowaIowa City, Iowa, United StatesRecruiting
University of KansasOverland Park, Kansas, United StatesCompleted
Johns Hopkins University HospitalBaltimore, Maryland, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Saint Louis UniversitySt Louis, Missouri, United StatesRecruiting
Wake Forest UniversityWinston-Salem, North Carolina, United StatesCompleted
Cleveland ClinicCleveland, Ohio, United StatesRecruiting
University of OklahomaOklahoma City, Oklahoma, United StatesRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT03295981