Condition: Type 1 Diabetes Mellitus · Sponsor: University of Maryland, Baltimore
(1) To determine how the Selective Serotonin Reuptake Inhibitor (SSRI), fluoxetine (Prozac), an antidepressant often used to treat depression, stimulates the participant's body's ability to defend against low blood sugar (hypoglycemia). (2) To learn how a hormone, dehydroepiandrosterone (DHEA), stimulates the participant's body's ability to defend itself from low blood sugar (hypoglycemia). DHEA is a hormone produced naturally in the human body. However, it can be manufactured and is sold as an over-the-counter dietary supplement. The dose the investigators are giving in this study is higher than the usual recommended dosage taken as a supplement for certain medical conditions. (3) To study combined effects of fluoxetine and DHEA during low blood glucose. In the present study, the investigators will measure the participant's body's responses to hypoglycemia when given fluoxetine or DHEA or fluoxetine and DHEA or a placebo (a pill with no fluoxetine or DHEA). Approximately 64 individuals with type 1 diabetes will take part in this study.
This description comes directly from the study's public registry record.
Maka Siamashvili, MD · 410-706-5623 · msiamashvili@som.umaryland.edu
Vanessa Briscoe, PhD · vbriscoe@som.umaryland.edu
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| University of Maryland | Baltimore, Maryland, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03228732