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Study identifier: NCT03215719 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma

Condition: Oropharyngeal Carcinoma · HPV Positive Oropharyngeal Squamous Cell Carcinoma  ·  Sponsor: NYU Langone Health

PhasePhase 2
Planned participants120
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase II clinical trial. The purpose of this study is to determine the feasibility of deescalating chemoradiation treatment based on mid-treatment tumor response determined by rapid nodal shrinkage and clearance of circulating HPV plasma tumor DNA . The primary objective of this study is to evaluate progression-free survival at 2 years.

This description comes directly from the study's public registry record.

Talk to the study team

Kenneth Hu  ·  212-731-5003  ·  Kenneth.Hu@nyulangone.org

Fraustina Hsu  ·  cancertrials@nyulangone.org

Always discuss trial participation with your own doctor first.

Locations (1)

New York University School of MedicineNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03215719