Condition: Atrial Arrhythmia · Atrial Tachycardia · Congenital Heart Disease · Sponsor: Ian Law
Congenital heart disease (CHD) affects approximately 1% of newborns in the US, with 25% of those affected having critical conditions requiring open heart surgery within one year of birth. Surgical and medical advances have allowed many patients to live beyond their fourth and fifth decades of life. Unfortunately, cardiac arrhythmias are a relatively common sequela due to cardiac anomalies and surgical scars in addition to residual volume and pressure load on the heart. Atrial arrhythmias, including sinus node dysfunction and intra-atrial re-entrant tachycardia (IART) are among the more common abnormalities found in adults with repaired CHD. The presence of IART significantly increases morbidity and mortality, and anti-arrhythmic medications have been shown to be a sub-optimal treatment strategy with the majority of patients requiring multi-drug therapy. Catheter ablation procedures remain a treatment option, but are less successful for some patient demographics. In the mid-1990's, pacemakers with atrial anti-tachycardia pacing (ATP) capabilities were developed, primarily for the management of atrial flutter and fibrillation in adults with structurally normal hearts. Given the need for pacemakers in the CHD population to manage sinus node dysfunction and atrioventricular node conduction block, the adoption of atrial anti-tachycardia pacemakers began to gain favor. However, there is limited data available comparing the safety and effectiveness of ATP therapy between various dem…
This description comes directly from the study's public registry record.
Ian Law, MD · 319-356-7303 · ian-law@uiowa.edu
Mackenzie K Clinical Trials Research Specialist · (319) 335-2643 · Ped-Card-Research@uiowa.edu
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| University of California, Los Angeles | Los Angeles, California, United States | Not Yet Recruiting |
| Children's Hospital of Orange County (CHOC) | Orange, California, United States | Recruiting |
| Memorial Healthcare System | Hollywood, Florida, United States | Not Yet Recruiting |
| Indiana University Health | Indianapolis, Indiana, United States | Not Yet Recruiting |
| University of Iowa Children's Hospital | Iowa City, Iowa, United States | Recruiting |
| Norton Healthcare | Louisville, Kentucky, United States | Recruiting |
| University of Michigan | Ann Arbor, Michigan, United States | Recruiting |
| Children's Hospital of Michigan | Detroit, Michigan, United States | Recruiting |
| Mayo Clinic | Rochester, Minnesota, United States | Not Yet Recruiting |
| Rainbow Babies and Children's Hospital | Cleveland, Ohio, United States | Not Yet Recruiting |
| Vanderbilt University Medical Center | Nashville, Tennessee, United States | Not Yet Recruiting |
| Baylor College of Medicine | Houston, Texas, United States | Recruiting |
+ 3 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03209583