Condition: Critical Illness · Vitamin D Deficiency · Covid19 · Sponsor: Medical University of Graz
In the VITdAL-ICU trial using a large oral dose of vitamin D3 in 480 adult critically ill patients, there was no benefit regarding the primary endpoint hospital length of stay. However, the predefined subgroup with severe vitamin D deficiency (25(OH)D ≤ 12ng/ml) had significantly lower 28-day mortality (36.3% placebo vs. 20.4% vitamin D group, hazard ratio (HR) 0.52 (0.30-0.89), number needed to treat = 6). Therefore, high-dose vitamin D3 in a population of severely vitamin D deficient critically ill patients is a promising and inexpensive intervention that requires confirmatory multicenter studies. To date, only 7 interventions (e.g. noninvasive ventilation or prone positioning) have ever demonstrated mortality benefit for Intensive Care Unit (ICU) patients in multicenter trials. In case of benefit, vitamin D treatment in critically ill patients could be immediately implemented worldwide.
This description comes directly from the study's public registry record.
Karin Amrein, MD, MSc · +43 681 · karin.amrein@medunigraz.at
Astrid Friedel · +43 316 385 · astrid.friedel@medunigraz.at
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| LKH Enzenbach | Enzenbach, Austria | Recruiting |
| LKH Feldbach | Feldbach, Austria | Terminated |
| Medical University of Graz | Graz, Austria | Recruiting |
| Klinikum am Wörthersee | Klagenfurt, Austria | Recruiting |
| LKH Hochsteiermark Standort Leoben | Leoben, Austria | Recruiting |
| Barmherzige Schwestern | Linz, Austria | Recruiting |
| Kepler Universitätsklinikum Linz | Linz, Austria | Recruiting |
| Krankenhaus Schwarzach | Schwarzach im Pongau, Austria | Terminated |
| Barmherzige Brüder | Vienna, Austria | Recruiting |
| Kaiser Franz Josef Spital Wien | Vienna, Austria | Suspended |
| Medical University of Vienna | Vienna, Austria | Recruiting |
| LKH Villach | Villach, Austria | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03188796