Condition: Autoimmune Liver Disease · Primary Sclerosing Cholangitis · Autoimmune Hepatitis · Sponsor: Children's Hospital Medical Center, Cincinnati
Autoimmune liver diseases (AILD), which include Primary Sclerosing Cholangitis (PSC) and Autoimmune Hepatitis (AIH) are a common etiological factors for chronic liver disease among adolescents. In all these conditions, autoimmune lymphocyte responses are thought to orchestrate inflammatory injury against hepatocytes (primarily in AIH) or cholangiocytes (in PSC). In this proposal we aim to evaluate the Magnetic Resonance Imaging (MRI) modalities; MR cholangiopancreatography (MRCP) and MR elastography (MREL), as non-invasive biomarkers to assess two primary pathophysiological processes of AILD: bile duct damage and liver fibrosis. In this cross-sectional study MRI based findings of bile duct injury and liver fibrosis will be correlated with both liver histology and circulating biomarkers of these disease processes.
This description comes directly from the study's public registry record.
Alexander Miethke, MD · 513-636-8948 · Alexander.Miethke@cchmc.org
Cyd Castro Rojas, PhD · 513-517-0580 · Cyd.CastroRojas@cchmc.org
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| Cincinnati Childrens Hospital Medical Center | Cincinnati, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03175471