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Study identifier: NCT03168581 Synced from ClinicalTrials.gov · July 28, 2026
● Completed

A Proof of Concept Study to Evaluate CN-105 in ICH Patients

Condition: Intracerebral Hemorrhage  ·  Sponsor: AegisCN LLC

PhasePhase 2
Planned participants38
Who can joinAll sexes, 30 Years to 80 Years
Healthy volunteersNo

About this study

A multicenter, open-label phase 2a trial of CN-105 in patients with supratentorial intracerebral hemorrhage (ICH). Patients will be evaluated for eligibility within 12 hours of symptom onset. Eligible participants (approximately 60) will receive CN-105 administered intravenously (IV) for a 30-minute infusion every 6 hours for up to a maximum of 3 days (13 doses) or until discharge (if earlier than 3 days). Participants will be monitored daily throughout the Treatment phase of the study (up to a maximum of 5 days) and will receive standard-of-care treatment for the duration of the study. Additional protocol assessments will be required during the Treatment phase. After discharge from the hospital, participants will enter a 3-month Follow-up phase, with a clinic visit at 30 days and a follow-up telephone interview with telephone-validated Modified Rankin Scale (mRS) at 90 days after first dose of study agent. Funding Source - FDA OOPD

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (5)

A.B. Chandler Medical Center-University of KentuckyLexington, Kentucky, United States
Duke University Health SystemDurham, North Carolina, United States
Wake Forest Baptist HealthWinston-Salem, North Carolina, United States
Medical University of South CarolinaCharleston, South Carolina, United States
University of Virginia Health SystemsCharlottesville, Virginia, United States

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Source record: clinicaltrials.gov/study/NCT03168581