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Study identifier: NCT03152058 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy

Condition: High Risk Pregnancy · Pregnancy Complications · Antiphospholipid Syndrome in Pregnancy  ·  Sponsor: David Ware Branch

PhasePhase 2
Planned participants55
Who can joinFemale, 18 Years to 40 Years
Healthy volunteersNo

About this study

This treatment trial evaluates the addition of an anti-tumor necrosis factor-alpha drug, certolizumab, to usual treatment (a heparin agent and low-dose aspirin) in pregnant women with antiphospholipid syndrome (APS) and repeatedly positive tests for lupus anticoagulant (LAC) to determine if this regimen will improve pregnancy outcomes. All enrolled patients will receive certolizumab, and pregnancy outcomes will be compared to those of women with APS and repeatedly positive tests for LAC enrolled in a previous study by the investigators.

This description comes directly from the study's public registry record.

Talk to the study team

Rose Peckham  ·  801-585-7617  ·  Rose.Peckham@hsc.utah.edu

Elizabeth Turner  ·  801-585-0591  ·  elizabeth.e.turner@hsc.utah.edu

Always discuss trial participation with your own doctor first.

Locations (3)

Hospital for Special SurgeryNew York, New York, United StatesRecruiting
University of UtahSalt Lake City, Utah, United StatesRecruiting
TRIO Advancing Reproductive CareToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT03152058