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Study identifier: NCT03150576 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Platinum and Polyadenosine 5'Diphosphoribose Polymerisation Inhibitor for Neoadjuvant Treatment of Triple Negative Breast Cancer and/or Germline BRCA Positive Breast Cancer

Condition: Breast Cancer  ·  Sponsor: Cambridge University Hospitals NHS Foundation Trust

PhasePhase 2/Phase 3
Planned participants780
Who can joinAll sexes, 16 Years to 70 Years
Healthy volunteersNo

About this study

This neoadjuvant trial for patients with TNBC and/or gBRCA breast cancer, aims to investigate the safety and efficacy (improvement in pathological Complete Response at surgery) of concurrent platinum-based chemotherapy with olaparib an inhibitor of the PARP enzyme (PARPi).

This description comes directly from the study's public registry record.

Talk to the study team

CCTC A Cambridge Cancer Trials Centre  ·  +44 (0)1223 348071  ·  cuh.partner@nhs.net

Always discuss trial participation with your own doctor first.

Locations (30)

Cambridge University Hospitals NHS Foundation Trust & the University of CambridgeCambridge, Cambridgeshire, United KingdomRecruiting
Queen's HospitalBurton-on-Trent, Derby, United KingdomRecruiting
The ChristieManchester, Lancs, United KingdomRecruiting
Pinderfields General HospitalWakefield, Yorkshire, United KingdomRecruiting
University Hospital AyrAyr, United KingdomRecruiting
Basingstoke and North Hampshire HospitalBasingstoke, United KingdomRecruiting
Bedford General HospitalBedford, United KingdomRecruiting
Royal Bournemouth HospitalBournemouth, United KingdomRecruiting
Bristol Haematology & Cancer CentreBristol, United KingdomRecruiting
West Suffolk HospitalBury St Edmunds, United KingdomRecruiting
Velindre Cancer CentreCardiff, United KingdomRecruiting
Colchester General HospitalColchester, United KingdomRecruiting

+ 18 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT03150576