Condition: Malignant Peripheral Nerve Sheath Tumors · Sponsor: Washington University School of Medicine
First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.
This description comes directly from the study's public registry record.
Angela Hirbe, M.D., Ph.D. · (314) 362-8965 · hirbea@wustl.edu
Always discuss trial participation with your own doctor first.
| Moffitt Cancer Center | Tampa, Florida, United States | Completed |
| Johns Hopkins | Baltimore, Maryland, United States | Recruiting |
| National Institutes of Health (NIH) | Bethesda, Maryland, United States | Not Yet Recruiting |
| Dana Farber Cancer Institute | Boston, Massachusetts, United States | Withdrawn |
| University of Minnesota | Minneapolis, Minnesota, United States | Withdrawn |
| Washington University School of Medicine | St Louis, Missouri, United States | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York, New York, United States | Not Yet Recruiting |
| Lifespan | Providence, Rhode Island, United States | Completed |
| University of Utah | Salt Lake City, Utah, United States | Completed |
| Mount Sinai | Toronto, Ontario, Canada | Recruiting |
| Global Gene Corporation | Mumbai, India | Completed |
| Nagoya University Hospital | Nagoya, Showa Ward, Japan | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT03141021