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Study identifier: NCT03128034 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

Condition: Acute Lymphoblastic Leukemia · Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome · Acute Myeloid Leukemia  ·  Sponsor: Fred Hutchinson Cancer Center

PhasePhase 1/Phase 2
Planned participants75
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This phase I/II trial studies the side effects and best dose of 211\^astatine(At)-BC8-B10 before donor stem cell transplant in treating patients with high-risk acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, or mixed-phenotype acute leukemia. Radioactive substances, such as astatine-211, linked to monoclonal antibodies, such as BC8, can bind to cancer cells and give off radiation which may help kill cancer cells and have less of an effect on healthy cells before donor stem cell transplant.

This description comes directly from the study's public registry record.

Talk to the study team

Brenda M. Sandmaier  ·  206-667-4961  ·  bsandmai@fredhutch.org

Always discuss trial participation with your own doctor first.

Locations (1)

Fred Hutch/University of Washington Cancer ConsortiumSeattle, Washington, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03128034