Condition: Hereditary Breast and Ovarian Cancer · Lynch Syndrome · Sponsor: University of Basel
Breast, colorectal, ovarian, and endometrial cancers constitute approximately 30% of newly diagnosed cancer cases in Switzerland and affect more than 12,000 individuals annually. Several hundred of these patients are likely to carry known genetic mutations associated with HBOC or LS. Genetic testing for hereditary susceptibility to cancer can prevent many cancer deaths through early identification and engagement in high-risk management care that involves intensive surveillance, chemoprevention and/or prophylactic surgery. However, current rates of genetic testing indicate that many Swiss mutation carriers and their family members do not use cancer genetic services (counseling and/or testing), either due to lack of coordination of care or due to lack of communication about the mutation among family members. Cascade screening identifies and tests family members of a known mutation carrier. It determines whether asymptomatic family members are carriers of the identified mutation and proposes management options to reduce harmful outcomes. Robust evidence of basic science and descriptive population-based studies in Switzerland support the necessity of cascade screening for HBOC and LS. However, translation of this knowledge into public health interventions is lacking. Specific Aims of the CASCADE study are: 1. Survey Index Patients diagnosed with HBOC or LS from clinic-based genetic testing records and determine their cancer status and surveillance practices; needs for coordina…
This description comes directly from the study's public registry record.
Maria C Katapodi, PhD · ++41791095163 · maria.katapodi@unibas.ch
Always discuss trial participation with your own doctor first.
| HFR Fribourg - Hôpital Cantonal | Fribourg, Canton of Fribourg, Switzerland | Not Yet Recruiting |
| Hirslanden Clinic Des Grangettes | Geneva, Canton of Geneva, Switzerland | Not Yet Recruiting |
| Hôpital du Jura Service d'Oncologie | Delémont, Canton of Jura, Switzerland | Recruiting |
| Katonsspital Winterthur Tumorzentrum Brustzentrum | Winterthur, Canton of Zurich, Switzerland | Not Yet Recruiting |
| University Hospital Basel | Basel, Switzerland | Recruiting |
| Istituto Oncologico della Zvizzera Italiana | Bellinzona, Switzerland | Recruiting |
| Gastroenterology clinic | Bern, Switzerland | Terminated |
| Universitatklinik fur Medizinische Onkologie, Inselspital | Bern, Switzerland | Recruiting |
| Unite d'Oncogenetique et de Prevention des Cancers | Geneva, Switzerland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03124212