Condition: Vomiting in Infants and/or Children · Nausea · Hematopoietic System--Cancer · Sponsor: The Hospital for Sick Children
Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents. Most children receiving highly emetogenic chemotherapy (HEC), including those receiving hematopoietic stem cell transplant (HSCT) conditioning, experience CIV despite receiving antiemetic prophylaxis. Olanzapine improves CINV control in adult cancer patients, has a track record of safe use in children with psychiatric illness, does not interact with chemotherapy and is inexpensive. We hypothesize that the addition of olanzapine to standard antiemetics will improve chemotherapy-induced vomiting (CIV) control in children receiving highly emetogenic chemotherapy
This description comes directly from the study's public registry record.
Lee Dupuis, RPh, PhD · 416-813-7762 · lee.dupuis@sickkids.ca
Muhammad Ali, MD · 416-813-7654 · muhammad.ali@sickkids.ca
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| University of California | San Francisco, California, United States | Recruiting |
| The Children's Mercy Hospital | Kansas City, Missouri, United States | Recruiting |
| Columbia University/Morgan Stanley Children's Hospital | New York, New York, United States | Withdrawn |
| University of North Carolina at Chapel Hill | Chapel Hill, North Carolina, United States | Recruiting |
| Nationwide Children's Hospital | Columbus, Ohio, United States | Recruiting |
| Medical University of South Carolina | Charleston, South Carolina, United States | Recruiting |
| Cancer Care Manitoba | Winnipeg, Manitoba, Canada | Recruiting |
| Hospital for Sick Children | Toronto, Ontario, Canada | Recruiting |
| Centre Hospitalier Universitaire Sainte-Justine, | Montreal, Quebec, Canada | Terminated |
| All India Institute of Medical Sciences | New Delhi, National Capital Territory of Delhi, India | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03118986