Condition: Asthma · Cough · Cough Variant Asthma · Sponsor: Dr. Diane Lougheed
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough. We hypothesize: 1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls. 2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).
This description comes directly from the study's public registry record.
M. Diane Lougheed, MD, MSc · 613-548-2348 · diane.lougheed@kingstonhsc.ca
Taylar Wall, RRT · 613-549-6666 · taylar.wall@kingstonhsc.ca
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| Kingston Health Sciences Centre | Kingston, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03105843