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Study identifier: NCT03099356 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Cyclophosphamide and Sirolimus for the Treatment of Metastatic, RAI-refractory, Differentiated Thyroid Cancer

Condition: Metastatic Thyroid Cancer  ·  Sponsor: University of Michigan Rogel Cancer Center

PhasePhase 2
Planned participants22
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will be a non-randomized pilot trial using Cyclophosphamide and Sirolimus for the treatment of metastatic differentiated thyroid cancer. Patients will be treated with Sirolimus 4 mg, PO, days 1-28 as well as Cyclophosphamide 100 mg, PO, days 1-5 and 15-19. Cycle length will be 28 days. Patients will be monitored closely for toxicity and undergo imaging to evaluate efficacy once every 2 cycles.

This description comes directly from the study's public registry record.

Talk to the study team

Cancer AnswerLine  ·  1-800-865-1125  ·  canceranswerline@umich.edu

Paul Swiecicki, M.D.  ·  pswiecic@med.umich.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Michigan Cancer CenterAnn Arbor, Michigan, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT03099356