Condition: Melanocytic Nevi · Sponsor: University of California, Davis
The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens. Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples: 1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis. 2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.
This description comes directly from the study's public registry record.
Maija Kiuru, MD · 916-734-0591 · mkiuru@ucdavis.edu
John Robb · 916-551-2636 · jmrobb@ucdavis.edu
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| University of California-Davis, Department of Dermatology | Sacramento, California, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03054584