Condition: Non-celiac Wheat Sensitivity · Sponsor: University of Palermo
Non-celiac gluten sensitivity (NCGS) is a condition where intestinal and extraintestinal symptoms are triggered by gluten ingestion in the absence of celiac disease and wheat allergy. Despite the great interest in NCGS, much remains unknown about the pathogenesis. Some studies seem to suggest that wheat components other than gluten (i.e. amylase/trypsine inhibitors, ATIs) can cause the symptoms, and therefore the term "non-celiac wheat sensitivity" (NCWS) has been proposed instead of NCGS. It is believed that this condition is worldwide increasing, due to the evolution of wheat breeding (i.e. consumption of wheats with high gluten content), and that ancient wheats are better tolerated by NCWS patients than the modern ones. Therefore, the aim of the study is to determine whether the common belief regarding the fact that ancient wheats are better tolerated by NCWS patients than the modern ones is confirmed by scientific data, and to identify the wheat kernel components triggering this pathology. The availability of wheat materials with opposite characteristics, such as the period of development (ancient vs. modern), or the technological properties (cultivars with weak glutens vs. strong gluten), or the presence/absence of specific ATIs polypeptides, will allow to define the role played by these factors. Therefore, the study has two objectives: 1) extraction and testing of total kernel proteins, in order to evaluate the inflammatory response to gluten and non-gluten proteins by …
This description comes directly from the study's public registry record.
Antonio Carroccio, PhD · +390916552884 · acarroccio@hotmail.com
Pasquale Mansueto, MD · +390916552884 · pasquale.mansueto@unipa.it
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| Department of Internal Medicine, Giovanni Paolo II Hospital of Sciacca | Sciacca, Agrigento, Italy | Recruiting |
| Department of Internal Medicine, University Hospital of Palermo | Palermo, Palermo, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT03024775