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Study identifier: NCT03016819 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)

Condition: Alveolar Soft Part Sarcoma · Leiomyosarcoma · Synovial Sarcoma  ·  Sponsor: Advenchen Laboratories, LLC

PhasePhase 3
Planned participants325
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

THIS STUDY IS CURRENTLY RECRUITING PATIENTS WITH ALVEOLAR SOFT PART SARCOMA ONLY AND IS NO LONGER RECRUITING PATIENTS WITH SYNOVIAL SARCOMA OR LEIOMYOSARCOMA. This study evaluates the safety and efficacy of AL3818 (anlotinib) hydrochloride in the treatment of metastatic or advanced alveolar soft part sarcoma (ASPS), leiomyosarcoma (LMS), and synovial sarcoma (SS). All participants with ASPS will receive open-label AL3818. In participants with LMS or SS, AL3818 will be compared to IV dacarbazine. Two-thirds of the participants will receive AL3818, one-third of the participants will receive IV dacarbazine.

This description comes directly from the study's public registry record.

Talk to the study team

Shiying Clinical Trial Manager  ·  8055301550  ·  Shiyings@advenchen.com

Judy Clinical Trial Manager  ·  8055301550  ·  judyc@advenchen.com

Always discuss trial participation with your own doctor first.

Locations (24)

Mayo Clinic ArizonaPhoenix, Arizona, United StatesCompleted
University of California Los AngelesLos Angeles, California, United StatesCompleted
Sarcoma Oncology CenterSanta Monica, California, United StatesRecruiting
Stanford Medicine Cancer InstituteStanford, California, United StatesCompleted
University of Colorado DenverAurora, Colorado, United StatesCompleted
Mayo Clinic JacksonvilleJacksonville, Florida, United StatesCompleted
University of Miami Sylvester Comprehensive Cancer CenterMiami, Florida, United StatesCompleted
Northwestern UniversityChicago, Illinois, United StatesCompleted
University of Michigan Comprehensive Cancer CenterAnn Arbor, Michigan, United StatesCompleted
Mayo Clinic RochesterRochester, Minnesota, United StatesCompleted
Washington University St. LouisSt Louis, Missouri, United StatesCompleted
Columbia University Medical CenterNew York, New York, United StatesWithdrawn

+ 12 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT03016819