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Study identifier: NCT02945579 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy

Condition: Estrogen Receptor Negative · HER2 Positive Breast Carcinoma · HER2/Neu Negative  ·  Sponsor: M.D. Anderson Cancer Center

PhaseNA
Planned participants120
Who can joinFemale, 30 Years to no upper limit
Healthy volunteersNo

About this study

This clinical trial studies eliminating surgery and/or radiation therapy in treating breast cancer patients. In HER2 positive and triple negative breast cancers, after systemic therapy, when image-guided biopsy shows no residual cancer, patients then receive standard breast radiotherapy with no surgery. In ER positive/HER2 negative breast cancers, after endocrine therapy and ablative radiotherapy, when image-guided biopsy shows no residual cancer, patients then receive standard endocrine therapy with no surgery. For patients who have HER2 positive and triple negative breast cancers and standard surgery, after systemic therapy, breast radiotherapy is being eliminated when the pathology from surgery shows no residual cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Henry Kuerer  ·  713-745-5043  ·  hkuerer@mdanderson.org

Always discuss trial participation with your own doctor first.

Locations (8)

MD Anderson Cancer Center - BannerGilbert, Arizona, United StatesCompleted
Baptist MD Anderson Cancer CenterJacksonville, Florida, United StatesRecruiting
Queen's Medical CenterHonolulu, Hawaii, United StatesCompleted
Mayo ClinicRochester, Minnesota, United StatesRecruiting
Cooper Hospital Univ Med Ctr, MD Anderson at Cooper VoorheesVoorhees Township, New Jersey, United StatesRecruiting
Carolinas Medical Center/Levine Cancer InstituteCharlotte, North Carolina, United StatesRecruiting
University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, Pennsylvania, United StatesRecruiting
M D Anderson Cancer CenterHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT02945579