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Study identifier: NCT02896335 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Palbociclib and Pembrolizumab In Central Nervous System Metastases

Condition: Metastatic Malignant Neoplasm to Brain · Recurrent Brain Metastases · Progressive Brain Metastases  ·  Sponsor: Massachusetts General Hospital

PhasePhase 2
Planned participants45
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research study is studying This research study is studying the efficacy and safety of the following study drugs as a possible treatment for recurrent central nervous system (CNS) metastases: * Palbociclib alone (Cohort 1) * The combination of palbociclib and pembrolizumab (Cohort 2) Pfizer and Merck, pharmaceutical companies, are supporting this research study by providing the study drugs as well as funding for research activities.

This description comes directly from the study's public registry record.

Talk to the study team

Nancy Wang, MD, MPH  ·  617-724-8770  ·  Nwang6@mgb.org

Always discuss trial participation with your own doctor first.

Locations (2)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT02896335