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Study identifier: NCT02889016 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS

Condition: Pediatric Acute-Onset Neuropsychiatric Syndrome · Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections · PANS  ·  Sponsor: Stanford University

PhaseN/A
Planned participants500
Who can joinAll sexes, 4 Years to 18 Years
Healthy volunteersYes

About this study

This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the abrupt, dramatic onset of obsessive compulsive disorder (OCD) and/or eating restriction accompanied by equally abrupt and severe co-morbid neuropsychiatric symptoms, which include anxiety, emotional lability, depression, irritability, aggression, oppositionality, deterioration in school performance, behavioral (developmental) regression, sensory amplification, movement abnormalities, sleep disturbance, and urinary frequency. PANS is thought to be caused by infection, inflammation, or alternate triggers that is associated with a brain response that leads to these symptoms. The purpose of this study is to examine specific neurologic, immunologic, rheumatologic, and genomic, components in children with the acute-onset of psychiatric symptoms. This research may begin to uncover a much larger story of autoimmune processes that are involved in psychiatric disorders of childhood. By better understanding the etiologic components of psychiatric phenomenon, future treatments may be better targeted to underlying causes.

This description comes directly from the study's public registry record.

Talk to the study team

Joanne Cheung  ·  pansresearch@stanford.edu

Ellen Spartz

Always discuss trial participation with your own doctor first.

Locations (1)

Stanford UniversityPalo Alto, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT02889016