Condition: Materials Testing · Sponsor: Universitaire Ziekenhuizen KU Leuven
In this randomized clinical trial, the bio-compatibility of 2 materials used for dental restorations will be compared: glass-ionomer vs resin-based composites. Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX. Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. Global alterations in DNA methylation and DNA hydroxymethylation levels will be determined using UPLC-MS/MS.
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| BIOMAT, Department of Oral Health Sciences | Leuven, Belgium | Recruiting |
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Source record: clinicaltrials.gov/study/NCT02874625