Condition: Severe Aplastic Anemia · Sponsor: Northside Hospital, Inc.
Severe aplastic anemia is a rare and serious form of bone marrow failure related to an immune-mediated mechanism that results in severe pancytopenia and high risk for infections and bleeding. Patients with matched sibling donors for transplantation have a 80-90% chance of survival; however, a response rate with just immunosuppression for those patients lacking suitable HLA-matched related siblings is only 60%. With immunosuppression, only 1/3 of patients are cured, 1/3 are dependent on long term immunosuppression, and the other 1/3 relapse or develop a clonal disorder. Recent studies have shown that using a haploidentical donor for transplantation has good response rates and significantly lower rates of acute and chronic GVHD.
This description comes directly from the study's public registry record.
Melhem Solh, MD · 404-255-1930 · msolh@bmtga.com
Stacey Brown · 404-851-8238 · stacey.brown@northside.com
Always discuss trial participation with your own doctor first.
| Blood and Marrow Transplant Group of Georgia | Atlanta, Georgia, United States | Recruiting |
| Northside Hospital | Atlanta, Georgia, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT02828592