Condition: Type 2 Diabetes · Proteinuria · Stress · Sponsor: University of Manitoba
The overall aim of the project is to elucidate the primary bio-psycho-social (BPS) risk factors for albuminuria in youth with type 2 diabetes (T2D) and the mechanisms by which they cause renal injury. The Study aims include: 1. Characterize the primary BPS risk factors associated with prevalent and progressive albuminuria in youth with T2D. 2. Determine individual, family and community level factors that influence biological and psychological risk factors and behaviors (adherence) that could be modified to protect against prevalent and progressive albuminuria. 3. Determine if systemic and renal inflammation is the common pathway through which BPS risk factors lead to albuminuria in youth with T2D. Study Hypotheses include: 1. Biological factors (poor glycemic control and systolic ambulatory hypertension), and psychological and social adversity (stress, mental distress and poverty) are significant predictors of prevalent and progressive albuminuria in youth with T2D. 2. Community and family support will be negatively associated with stress, and a lower risk of both prevalent and progressive albuminuria. 3. Systemic and renal inflammation is the common pathway through which BPS risk factors lead to albuminuria in youth with T2D.
This description comes directly from the study's public registry record.
Brandy A Wicklow, MD, MSc · 2047871222 · bwicklow@hsc.mb.ca
Melissa Del Vecchio, MSc · 2047893827 · mdelvecchio@chrim.ca
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| Children's Hospital Research Institute of Manitoba/University of Manitoba | Winnipeg, Manitoba, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT02818192